The convergence of climate change, resource degradation, geopolitical instability, and economic shocks has intensified a set of interconnected “polycrises” across the food, energy, water, and environment (FEWE) nexus. These overlapping pressures are reshaping agri-food systems globally, with disproportionate impacts on vulnerable populations and smallholder producers. Drawing on ongoing work from the Agrifood Innovation and Resilience Unit at the International Food Policy Research Institute (IFPRI), the presentation identifies key entry points for integrated policy and investment responses highlighting nexus approaches to uncover synergies and manage trade-offs between competing resource demands.